The Hong Laboratory

Bangxing Hong, PhD

Assistant Professor, Department of Pathology
Georgia Cancer Center
Medical College of Georgia at 51ｳﾔｹﾏｺﾚﾁﾏﾆﾘﾁﾏ

Jump to: Research Summmary Research Interests Selected Publications Research Team

Contact Us

The Bangxing Hong Lab

Health Sciences Campus

1410 Laney Walker Blvd., CN-3112

(706) 721-1187

bhong@augusta.edu

Research Summary

The Hong laboratory is interested in developing novel immunotherapy through modulation of antigen presentation activity of dendritic cells, generation of antigen specific T cell-based cell therapy or developing oncolytic virus-based immunotherapy to target incurable tumor including glioblastoma, lymphoma, and other solid tumors.

Research Interests

State of the art technologies including CyTOF, scRNA-seq and proteomics are been used in our study. Ongoing projects include:

Oncolytic Virotherapy:

Oncolytic virotherapy is an emerging novel treatment for cancer patients. HSV-1-based oncolytic virus has been approved for metastatic cancer and relapse glioblastoma treatment. We are developing HSV-1 based oncolytic virus that disabling tumor-intrinsic and tumor-extrinsic factors that limit oncolytic virus infection, replication, and induction of anti-tumor immune response (JITC 2025; Molecular Cancer Therapeutics 2024; JITC窶ｯ2023;窶ｯClinical Cancer Research窶ｯ2021).窶ｯ筝ﾄｯ

Modulation Antigen Presentation for Immunotherapy:

Through modulation the activities of antigen presentation attenuators (APAs), such as SOCS1 and A20, in antigen presentation cells (dendritic cells), we can reverse the tolerization of dendritic cells and generation of strong adaptive immune response again cancer (JITC 2023; Cancer Research 2009) or HIV(JCI 2011).

T cell Immunotherapy:

We develop antigen specific T cells including cytotoxic T lymphocytes (CTLs), Th9 or Tc9 cells to induce strong anti-tumor immune response against solid tumor through modulation of immune suppressive signaling in tumor microenvironment (Gene Therapy 2012; PNAS2014; JCI2011; JCI2012).

Selected Publications

Tsuboi N, Rivera-Caraballo KA, Sahu U, Pacholczyk R, Douglass E, Johnson TS, Wang Q, Kolhe R, Hedrick CC, Munn DH, Hong B*. Blocking feedback immunosuppression of antigen presentation in brain tumor during oncolytic virotherapy with oHSV-mshPKR. Molecular Cancer Therapeutics, 2024, doi:10.1158/1535-7163. (* Corresponding author)
Kyritsi K, Pacholczyk R, Douglass E, Yu M, Fang H, Zhou G, Kaur B, Wang Q, Munn DH, Hong B*. b-blocker suppresses both tumoral sympathetic neurons and perivascular macrophages during oncolytic herpes virotherapy. The Journal for Immunotherapy of Cancer, 2025, In press. (* Corresponding author)

Additional Publications

Publication
Tsuboi, N., Rivera-Caraballo, K. A., Sahu, U., , Douglass, E., , , , , & , Mar 4 2025, In: Molecular cancer therapeutics. 24, 3, p. 444-452 9 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Qin, A., Shi, K., Tindall, R. R., Li, J., Cheng, B., Li, J., Yang, B., Yu, Q., Zhang, Y., , , Younes, M., Shen, Q., Bailey-Lundberg, J. M., Cao, Y. & Ko, T. C., Jan 2025, In: Gastro Hep Advances. 4, 2, 100557. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
He, J., Liu, Z., Zheng, Y., Qian, J., Li, H., Lu, Y., Xu, J., , Zhang, M., Lin, P., Cai, Z., Orlowski, R. Z., Kwak, L. W., Yi, Q. & Yang, J., Dec 15 2012, In: Cancer Research. 72, 24, p. 6393-6402 10 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Sahu, U., Mullarkey, M. P., Pei, G., Zhao, Z., & , Jun 15 2023, In: Molecular Therapy Oncolytics. 29, p. 30-41 12 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Swanner, J., Shim, J. S., Rivera-Caraballo, K. A., Vﾃ｡zquez-Arreguﾃｭn, K., , Bueso-Perez, A. J., Lee, T. J., Banasavadi-Siddegowda, Y. K., & Yoo, J. Y., Mar 16 2023, In: Molecular Therapy Oncolytics. 28, p. 171-181 11 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Sahu, U., Mullarkey, M. P., Hong, E., Pei, G., Yan, Y., Otani, Y., Banasavadi-Siddegowda, Y., Fan, H., Zhao, Z., Yu, J., Caligiuri, M. A. & , Feb 16 2023, In: Journal for ImmunoTherapy of Cancer. 11, 2, e006164. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Song, X. T., Rollins, L., Berry, L., Huang, X. F. & Chen, S. Y., Feb 1 2011, In: Journal of Clinical Investigation. 121, 2, p. 739-751 13 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Jiang, L. F., Hu, Y. S., Fang, D. Y. & Guo, H. Y., Mar 2004, In: Chinese Journal of Microbiology and Immunology. 24, 3, p. 241-244 4 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Dang, R. J., Yang, Y. M., Zhang, L., Cui, D. C., , Li, P., Lin, Q., Wang, Y., Wang, Q. Y., Xiao, F., Mao, N., Wang, C., Jiang, X. X. & Wen, N., Aug 1 2016, In: Journal of Cellular and Molecular Medicine. 20, 8, p. 1550-1560 11 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Lu, Y., Hong, S., Li, H., Park, J., , Wang, L., Zheng, Y., Liu, Z., Xu, J., He, J., Yang, J., Qian, J. & Yi, Q., Nov 1 2012, In: Journal of Clinical Investigation. 122, 11, p. 4160-4171 12 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Jiang, L. F., Hu, Y. S., Fang, D. Y. & Guo, H. Y., Sep 2004, In: Journal of Microbiological Methods. 58, 3, p. 403-411 9 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Lee, S. H., Song, X. T., Jones, L., Machida, K., Huang, X. F. & Chen, S. Y., Nov 7 2012, In: PloS one. 7, 11, e48614. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Song, X. T., Turnis, M. E., Zhou, X., Zhu, W., , Rollins, L., Rabinovich, B., Chen, S. Y., Rooney, C. M. & Gottschalk, S., Jan 2011, In: Molecular Therapy. 19, 1, p. 211-217 7 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Zhang, M., Qian, J., Lan, Y., Lu, Y., Li, H., , Zheng, Y., He, J., Yang, J. & Yi, Q., Sep 1 2014, In: International Journal of Cancer. 135, 5, p. 1132-1141 10 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Li, H., Zhang, M., Xu, J., Lu, Y., Zheng, Y., Qian, J., Chang, J. T., Yang, J. & Yi, Q., Jan 1 2015, In: International Journal of Cancer. 136, 1, p. 34-43 10 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Li, H., Lu, Y., Zhang, M., Zheng, Y., Qian, J. & Yi, Q., May 31 2014, In: Molecular cancer. 13, 1, 132. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Park, J., Li, H., Zhang, M., Lu, Y., , Zheng, Y., He, J., Yang, J., Qian, J. & Yi, Q., Aug 2014, In: Cancer Immunology, Immunotherapy. 63, 8, p. 835-845 11 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Wang, D., Huang, X. F., , Song, X. T., Hu, L., Jiang, M., Zhang, B., Ning, H., Li, Y., Xu, C., Lou, X., Li, B., Yu, Z., Hu, J., Chen, J., Yang, F., Gao, H., Ding, G., Liao, L. & Rollins, L. & 3 others, Jones, L., Chen, S. Y. & Chen, H., Feb 8 2018, In: JCI Insight. 3, 3 Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Liu, Z., Xu, J., Li, H., Zheng, Y., He, J., Liu, H., Zhong, Y., Lu, Y., , Zhang, M., Lin, P., Du, J., Hou, J., Qian, J., Kwak, L. W., Yi, Q. & Yang, J., Dec 10 2013, In: PloS one. 8, 12, e82453. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Wang, L., , Jiang, X., Jones, L., Chen, S. Y. & Huang, X. F., Nov 7 2012, In: PloS one. 7, 11, e48930. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Huang, X. F., Nandakumar, V., Tumurkhuu, G., Wang, T., Jiang, X., , Jones, L., Won, H., Yoshii, H., Ozato, K., Masumi, A. & Chen, S. Y., 2016, In: Cell Death and Disease. 7, 6, e2260. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Jiang, L. & Zhang, X., Sep 2000, In: Chinese Journal of Microbiology and Immunology. 20, 5, p. 477-480 4 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Peng, G., Berry, L., Gottschalk, S., Jung, J. U., Chen, S. Y. & Huang, X. F., Aug 2012, In: Gene Therapy. 19, 8, p. 818-827 10 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Lee, S. H., , Sharabi, A., Huang, X. F. & Chen, S. Y., Jul 2009, In: Stem Cells. 27, 7, p. 1604-1615 12 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Ren, W., Song, X. T., Evel-Kabler, K., Chen, S. Y. & Huang, X. F., Oct 15 2009, In: Cancer Research. 69, 20, p. 8076-8084 9 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Lu, Y., , Li, H., Zheng, Y., Zhang, M., Wang, S., Qian, J. & Yi, Q., Feb 11 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 6, p. 2265-2270 6 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Lu, Y., Zhang, M., Wang, S., , Wang, Z., Li, H., Zheng, Y., Yang, J., Davis, R. E., Qian, J., Hou, J. & Yi, Q., Jun 24 2014, In: Nature communications. 5, 4229. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Chapa, V., Saini, U., Modgil, P., Cohn, D. E., He, G., Siddik, Z. H., Sood, A. K., Yan, Y., Selvendiran, K., Pei, G., Zhao, Z., Yoo, J. Y. & , Jan 15 2021, In: Clinical Cancer Research. 27, 2, p. 542-553 12 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
Otani, Y., Yoo, J. Y., Lewis, C. T., Chao, S., Swanner, J., Shimizu, T., Kang, J. M., Murphy, S. A., Rivera-Caraballo, K., , Glorioso, J. C., Nakashima, H., Lawler, S. E., Banasavadi-Siddegowda, Y., Heiss, J. D., Yan, Y., Pei, G., Caligiuri, M. A., Zhao, Z. & Antonio Chiocca, E. & 2 others, Yu, J. & , Apr 1 2022, In: Clinical Cancer Research. 28, 7, p. 1460-1473 14 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review
, Muili, K., Bolyard, C., Russell, L., Lee, T. J., Banasavadi-Siddegowda, Y., Yoo, J. Y., Yan, Y., Ballester, L. Y., Bockhorst, K. H. & , Mar 29 2019, In: Molecular Therapy Oncolytics. 12, p. 93-102 10 p. Research output: Contribution to journal 窶ｺ Article 窶ｺ peer-review

Research Team

Meenaskhi Ahluwalisa, PhD

Postdoctoral Fellow

Konstantina Kyritsi, PhD

Postdoctoral Fellow

Hailey Garner

2025 ALSF POST Scholar

Jishi Ye, MD/PhD

Visiting Fellow

Nobushige Tsuboi, PhD

Research Associate

Reducing the Burden

The Georgia Cancer Center at 51ｳﾔｹﾏｺﾚﾁﾏﾆﾘﾁﾏ is dedicated to reducing the burden of cancer in Georgia and across the globe through superior care, innovation, and education. Through unprecedented expansion, the Georgia Cancer Center is providing access to more first-in-the-nation clinical trials, world-renowned experts and life-saving options.