Email: dmor@augusta.edu
Mailing Address:
Dept. of Neuroscience
& Regenerative Medicine
1120 15th Street, Rm. CA4014
Medical College of Georgia
at 51吃瓜黑料曝料
51吃瓜黑料曝料, GA 30912
Education:
2010-2016 Ph.D. in Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA
2006-2010 B.A. in Neuroscience and Behavior, Wesleyan University, Middletown, CT
Training:
2016-2020 Postdoctoral Fellowship, Princeton University, Princeton, NJ
鈥淲e use the nematode worm, C. elegans, to study age-related disease phenotypes,
including neurodegeneration and protein aggregation.鈥�
Research Interests:
Parkinson鈥檚 disease, neurodegeneration, aging, microbiome in disease
The main goal of my research is to identify mechanisms and modifiers of 伪-synuclein toxicity in Parkinson鈥檚 disease, using the nematode worm C. elegans. Parkinson鈥檚 is an age-related neurodegenerative disorder in which patients experience both motor and non-motor symptoms. A defining feature of the disease is the formation of abnormal protein aggregates containing 伪-synuclein, yet the causes and consequences of 伪-synuclein aggregation remain unclear. Increasing evidence suggests that 伪-synuclein pathology may first appear in neurons innervating the gastrointestinal tract, and may spread in a prion-like manner to the central nervous system. Our research focuses on identifying the factors that regulate 伪-synuclein prion-like spread and neurotoxicity, using a combination of high-resolution imaging, cell type-specific RNA-sequencing, metabolomics, and high-throughput genetic and drug screening approaches. Another major interest of the lab is to understand the role of diet and the microbiome in Parkinson鈥檚 disease.
Selected Publications:
