We are an internationally diverse group of scientists who share a common passion: scientific discovery. Here at AU, we blend our expertise and creativity to discover new ways to harness the power of the immune system to treat disease. If you are interested in joining our team, please email us!
Atherosclerosis is a disease characterized by elevated circulating lipid levels, as well as contributions of the immune system. Our laboratory explores the influence of dysregulated lipid metabolism, as occurs during atherosclerosis, on pathologic immune cell formation and function. Projects will focus on the identification regulators/pathways that become dysregulated during disease progression and therapeutic strategies to mediate the pathologic contributions of immune cells in cardiovascular disease, inflammatory disorders and cancer.
We use high resolution microscopy and flow cytometry combined with reporter mouse models to decipher changes in immune cells and their microenvironment between health and disease. Our goal is to identify pharmacologically relevant avenues of intervention to slow or even reverse disease.
Adil Rasheed, PhD
Canada
Kateryna Fesenkova, DMD
Ukraine
Rachel Anne Iannotti, MPH
United States of America
Understanding the molecular mechanisms underlying foam cell development in the atherosclerotic plaque
Assessing and mediating the influence of nutrient metabolism on immune cell phenotype
Identification of factors that influence the progression of atherosclerosis and advancement of the plaque
Investigate the adaptations of the hematopoietic niche in cardiovascular disease
