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Medical College of GeorgiaImmunology Center of Georgia
Immunology Center of Georgia
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  • Immunology Center of Georgia

Klaus Ley Lab

 

Who We Are

The Ley lab studies atherosclerosis, the pathomechanism underlying most cardiovascular disease. We focus on the adaptive immune system. We work on the autoimmune aspect of atherosclerosis, mainly on the CD4 and CD8 T cell responses.


Dr. Klaus Ley

 

 

Klaus Ley, M.D.

Founding Co-Director, Immunology Center of Georgia (IMMCG)
Georgia Research Alliance Bradley Turner Eminent Scholar in Immunology
Professor, Department of Physiology
Medical College of Georgia at 51吃瓜黑料曝料

 

 

What We Study

The lab uses human samples from patients with the disease we study: cardiovascular disease including coronary artery disease. Major methods we use:

  • Human blood leukocytes: single cell RNA sequencing with surface phenotype by CITE-Seq
  • Spectral flow cytometry
  • Bioinformatics: noise reduction methods, gene signatures
  • T cell receptor sequencing
  • Epitope identification
  • Cell type discovery
  • Lineage tracker mice
  • Reporter mice
  • Knockout and knockin mice
  • Intravital microscopy

Contact Us

Immunology Center of Georgia (IMMCG)

 Health Sciences Campus

1410 Laney Walker Blvd, CN2119

kley@augusta.edu

706-446-0296

Research Team

photo of Anusha Bellapu

Anusha Bellapu

  • Bioinformatician 2

India flag

 India

photo of Michael Nakama, MS

Michael Nakama, MS

  • Research Manager

United States of America flag

United States of America

photo of Pei Xiong Liew, PhD

Pei Xiong Liew, PhD

  • Senior Research Scientist

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Singapore

photo of Mikhail Fomin, MSc

Mikhail Fomin, MSc

  • Research Associate

United States of America flag

United States of America

photo of Qingkang Lyu, PhD

Qingkang Lyu, PhD

  • Postdoc

Chinese Flag

China

photo of Smriti Parashar, PhD

Smriti Parashar, PhD

  • Postdoc

India flag

 India

photo of Sunil Kumar, Ph.D.

Sunil Kumar, Ph.D.

  • Postdoc

India flag

 India

photo of Yan Wang, PhD

Yan Wang, PhD

  • Postdoc

Chinese Flag

China

photo of Megh Mehta

Megh Mehta

  • Graduate Research Assistant

United States of America flag

United States of America

photo of Aderonke Fakayode

Aderonke Fakayode

  • Graduate Research Assistant

Flag of NigeriaNigeria

Current Research Interests

  • High-dimensional data generated by single-cell RNA sequencing
  • Integrin activation in immune cells
  • Autoimmune response to ApoB and the potential to apply this to develop a vaccine for atherosclerosis
  • Understanding a newly discovered type of olfactory receptors in macrophages and their role in atherosclerosis
  • Understanding differences in the immune response of diverse populations to atherosclerosis

 

Publication
​

Wu, Y., Cao, Z., Liu, W., Cahoon, J. G., Wang, K., Wang, P., Hu, L., Chen, Y., Moser, M., Vella, A. T., , Wen, L. & Fan, Z., Dec 2025, In: Cell Communication and Signaling. 23, 1, 12.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Nettersheim, F. S., Brunel, S., Sinkovits, R. S., Armstrong, S. S., Roy, P., Billitti, M., Kobiyama, K., Alimadadi, A., , Lu, L., Zoccheddu, M., Oliaeimotlagh, M., Benedict, C. A., Sette, A. & , Jan 2025, In: Nature Immunology. 26, 1, p. 105-115 11 p., 812769.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Suthahar, S. S. A., Nettersheim, F. S., Alimadadi, A., Wang, E., Billitti, M., Resto-Trujillo, N., Roy, P., , & , Sep 1 2024, In: Cardiovascular Research. 120, 13, p. 1577-1589 13 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Sl眉tter, B. & , 2024, In: Frontiers in immunology. 15, 1440283.

Research output: Contribution to journal 鈥 Editorial 鈥 peer-review

​

Frias-Anaya, E., Gallego-Gutierrez, H., Gongol, B., Weinsheimer, S., Lai, C. C., , Sriram, A., Bui, C. M., Nelsen, B., Hale, P., Pham, A., Shenkar, R., Debiasse, D., Lightle, R., Girard, R., Li, Y., Srinath, A., Daneman, R., Nudleman, E. & Sun, H. & 8 others, Guma, M., Dubrac, A., Mesarwi, O. A., , Kim, H., Awad, I. A., Ginsberg, M. H. & Lopez-Ramirez, M. A., Jun 1 2024, In: Arteriosclerosis, thrombosis, and vascular biology. 44, 6, p. 1246-1264 19 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Roy, P., Suthahar, S. S. A., Makings, J. & , 2024, In: Frontiers in immunology. 15, 1302031.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Khan, A. & , Jul 2024, In: Cell Research. 34, 7, p. 467-468 2 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Stroope, C., Nettersheim, F. S., Coon, B., Finney, A. C., Schwartz, M. A., , Rom, O. & Yurdagul, A., Apr 2024, In: Nature Metabolism. 6, 4, p. 617-638 22 p.

Research output: Contribution to journal 鈥 Review article 鈥 peer-review

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Gazzi, A., Fusco, L., , Keshavan, S., Shin, Y., Grivel, J. C., Rinchai, D., Ahmed, E. I., Elhanani, O., Furesi, G., Rauner, M., Keren, L., , Casiraghi, C., Bedognetti, D., Fadeel, B. & Delogu, L. G., Feb 2024, In: Nano Today. 54, 102084.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Chatterjee, N., , Durant, C. P., Wu, R., McSkimming, C., Drago, F., Kumar, S., Valentin-Guillama, G., Miller, Y. I., McNamara, C. A., , Taylor, A., Alimadadi, A. & , Mar 2024, In: International journal of molecular sciences. 25, 5, 2894.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Khan, A., Roy, P. & , Sep 2024, In: Nature Reviews Immunology. 24, 9, p. 670-679 10 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Pattarabanjird, T., Srikakulapu, P., Ransegnola, B., Marshall, M. A., Ghosheh, Y., Gulati, R., Durant, C., Drago, F., Taylor, A. M., & McNamara, C. A., 2023, In: Frontiers in immunology. 14, 1296668.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Iqneibi, S., Saigusa, R., Khan, A., Oliaeimotlagh, M., Armstrong Suthahar, S. S., Kumar, S., Alimadadi, A., Durant, C. P., Ghosheh, Y., McNamara, C. A., & , 2023, In: Frontiers in immunology. 14, 1239148.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Kiss, M. G., Papac-Mili膷evi膰, N., Porsch, F., Tsiantoulas, D., Hendrikx, T., Takaoka, M., Dinh, H. Q., Narzt, M. S., G枚derle, L., Ozsv谩r-Kozma, M., Schuster, M., Fortelny, N., Hladik, A., Knapp, S., Gruber, F., Pickering, M. C., Bock, C., Swirski, F. K., & Zernecke, A. & 4 others, Cochain, C., Kemper, C., Mallat, Z. & Binder, C. J., Aug 8 2023, In: Immunity. 56, 8, p. 1809-1824.e10

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Slysz, J., Sinha, A., DeBerge, M., Singh, S., Avgousti, H., Lee, I., Glinton, K., Nagasaka, R., Dalal, P., Alexandria, S., Wai, C. M., Tellez, R., Vescovo, M., Sunderraj, A., Wang, X., Schipma, M., Sisk, R., Gulati, R., Vallejo, J. & Saigusa, R. & 8 others, Lloyd-Jones, D. M., Lomasney, J., Weinberg, S., Ho, K., , Giannarelli, C., Thorp, E. B. & Feinstein, M. J., 2023, In: JCI Insight. 8, 17, e171359.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Lyu, Q., Wang, Y. & , Aug 2023, In: Journal of Leukocyte Biology. 114, 2, p. 109-110 2 p.

Research output: Contribution to journal 鈥 Editorial 鈥 peer-review

​

Pattarabanjird, T., Nguyen, A. T., McSkimming, C., Dinh, H. Q., Marshall, M. A., Ghosheh, Y., Gulati, R., Durant, C., Vallejo, J., Saigusa, R., Drago, F., Guy, T. V., Premo, K., Taylor, A. M., Paul, S., Kundu, B., Berr, S., Gonen, A., Tsimikas, S. & Miller, Y. & 4 others, Pillai, S., , & McNamara, C. A., Dec 2023, In: Nature Cardiovascular Research. 2, 12, p. 1328 1 p.

Research output: Contribution to journal 鈥 Comment/debate 鈥 peer-review

​

Pattarabanjird, T., Wilson, J. M., Erickson, L. D., Workman, L. J., Qiao, H., Ghosheh, Y., Gulati, R., Durant, C., Vallejo, J., Saigusa, R., Platts-Mills, T. A. E., Taylor, A. M., & McNamara, C. A., 2021, In: Frontiers in Cardiovascular Medicine. 8, 791028.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Nettersheim, F. S., Braumann, S., Kobiyama, K., , Vassallo, M., Miller, J., Ali, A., Roy, P., Saigusa, R., Wolf, D., & Winkels, H., 2021, In: Frontiers in Cardiovascular Medicine. 8, 812769.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Pattarabanjird, T., Nguyen, A. T., McSkimming, C., Dinh, H. Q., Marshall, M. A., Ghosheh, Y., Gulati, R., Durant, C., Vallejo, J., Saigusa, R., Drago, F., Guy, T. V., Premo, K., Taylor, A. M., Paul, S., Kundu, B., Berr, S., Gonen, A., Tsimikas, S. & Miller, Y. & 4 others, Pillai, S., , & McNamara, C. A., Nov 2023, In: Nature Cardiovascular Research. 2, 11, p. 1003-1014 12 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

​

Freuchet, A., Roy, P., Armstrong, S. S., Oliaeimotlagh, M., Kumar, S., , Ali, A. J., Khan, A., Makings, J., Lyu, Q., Winkels, H., Wang, E., Durant, C., Ghosheh, Y., Gulati, R., Nettersheim, F. & , Oct 2023, In: Nature Immunology. 24, 10, p. 1748-1761 14 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Saigusa, R., Roy, P., Freuchet, A., Gulati, R., Ghosheh, Y., Armstrong Suthahar, S. S., Durant, C. P., Hanna, D. B., Kiosses, W. B., , Wen, L., Wu, R., Kuniholm, M. H., Landay, A. L., Anastos, K., Tien, P. C., Gange, S. J., Kassaye, S., Vallejo, J. & & 5 others, Kwok, W. W., Sette, A., Hodis, H. N., Kaplan, R. C. & , May 2022, In: Nature Cardiovascular Research. 1, 5, p. 462-475 14 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Wang, Z., Zhang, X., Lu, S., Zhang, C., Ma, Z., Su, R., Li, Y., Sun, T., Li, Y., Hong, M., Deng, X., Rafiee Monjezi, M., Hristov, M., Steffens, S., Santovito, D., Dornmair, K., , Weber, C., Mohanta, S. K. & Habenicht, A. J. R. & 1 others, Yin, C., Mar 2023, In: Nature Cardiovascular Research. 2, 3, p. 290-306 17 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Zernecke, A., Erhard, F., Weinberger, T., Schulz, C., , Saliba, A. E. & Cochain, C., Jun 1 2023, In: Cardiovascular Research. 119, 8, p. 1676-1689 14 p.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Fusco, L., Gazzi, A., Shuck, C. E., , Ahmed, E. I., Giro, L., Zavan, B., Yilmazer, A., , Bedognetti, D., Gogotsi, Y. & Delogu, L. G., Aug 18 2023, In: Small Methods. 7, 8, 2300197.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Lin, J., Ehinger, E., Hanna, D. B., Qi, Q., Wang, T., Ghosheh, Y., Mueller, K., Anastos, K., Lazar, J. M., Mack, W. J., Tien, P. C., Berman, J. W., Cohen, M. H., Ofotokun, I., Gange, S., Liu, C., Heath, S. L., Tracy, R. P., Hodis, H. N. & Landay, A. L. & 2 others, & Kaplan, R. C., May 2023, In: PloS one. 18, 5 May, e0285926.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Lyu, Q. & , Feb 1 2023, In: Arteriosclerosis, thrombosis, and vascular biology. 43, 2, p. 215-217 3 p.

Research output: Contribution to journal 鈥 Editorial 鈥 peer-review

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Nettersheim, F. S., Ghosheh, Y., Winkels, H., Kobiyama, K., Durant, C., Armstrong, S. S., Brunel, S., Roy, P., Dileepan, T., Jenkins, M. K., Zajonc, D. M. & , Jan 5 2023, In: Frontiers in Cardiovascular Medicine. 9, 1076808.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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Li, W., Wen, L., Rathod, B., Gingras, A. C., & Lee, H. S., Mar 1 2023, In: Life Science Alliance. 6, 3

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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, Wolf, D., Suryawanshi, V., Winkels, H., Kobiyama, K., Makings, J., Kiosses, W. B. & , Jan 2023, In: Cellular and Molecular Life Sciences. 80, 1, 10.

Research output: Contribution to journal 鈥 Article 鈥 peer-review

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